Essential information about LEROCHOL for your practice, including cash-pay access
LEROCHOL Overview
Resources for your practice and patients
Downloadable Resources
Information for your patients about LEROCHOL including details on the cash-pay offer and tips to stay on treatment
Patient Brochure
Step-by-step instructions for your patients detailing how to take LEROCHOL
Instructions for UseVideos
Meet Adriane
A real patient navigating life with FH
Listen to her story about her long journey to diagnosis, time in the clinical trial for LEROCHOL, and how her experience taking PCSK9 inhibitors helped her realize what matters most to her in a treatment. Adriane was compensated for her time.
A Doctor & Patient Perspective
Hear a conversation between Dr. Evan Stein and Adriane, a real patient, where they discuss her journey to finding an accurate diagnosis and the right LDL-C-lowering treatment for her needs: LEROCHOL. Adriane was compensated for her time.
Frequently Asked Questions
What is LEROCHOL?
LEROCHOL is a novel, third-generation PCSK9 inhibitor indicated as an adjunct to diet and exercise to reduce LDL-C in adults with hypercholesterolemia, including those with HeFH.
Cardiovascular outcomes trials have demonstrated that reducing LDL‑C lowers the risk for major adverse cardiovascular events (MACE) in adults at increased risk when treated with statins or monoclonal antibody PCSK9 inhibitors as an add-on to statin therapy.1,2
LEROCHOL delivers:
- Robust, sustained LDL-C lowering up to 60% over 52 weeks1–3*
- A once-monthly, self-administered, subcutaneous injection2
- Extended room temperature storage for up to 3 months2†
How is LEROCHOL administered?
LEROCHOL is self-administered subcutaneously once monthly via a small-volume, prefilled syringe, delivering convenience for patients even while on the go.2 The Instructions for Use Reference Guide is available to offer patients step-by-step instructions for taking LEROCHOL.
Does LEROCHOL need to be refrigerated?
LEROCHOL does not need refrigeration and can be stored at room temperature for up to 3 months, offering convenience for patients who frequently travel or need more flexibility. If LEROCHOL is not refrigerated for more than 3 months, it must be discarded.2
What should I do if a patient misses their dose?
If a patient misses their dose by less than 7 days, instruct them to administer LEROCHOL as soon as possible and resume their original monthly dosing schedule.2
If a patient misses their dose by more than 7 days, instruct them to administer LEROCHOL as soon as possible and start a new monthly dosing schedule based on the new date.2
What makes LEROCHOL a different PCSK9 inhibitor?
LEROCHOL is a small-binding protein PCSK9 inhibitor self-administered as a single, small-volume, subcutaneous injection once a month, with extended room-temperature stability (up to 3 months), designed with the convenience patients need to stay on treatment.1,3*†
Can I switch a patient to LEROCHOL if they are already prescribed a different PCSK9 inhibitor medication?
Yes, a healthcare provider may determine if a patient is appropriate to be switched to LEROCHOL from another PCSK9 inhibitor based on the patient’s individual treatment needs and there are no other clinical considerations.
View LEROCHOL’s full Prescribing Information.
Patient Advocacy Resources
Below are links to advocacy groups that specialize in supporting and empowering patients and their families and also highlight research insights and guidelines information.
Family Heart
Foundation
Visit FHF American Heart Association
Visit AHAFoundation of the National Lipid Association
Visit Foundation of the NLAThe Mended
Hearts, Inc.
Visit MHI Publications
For additional information and context regarding LEROCHOL, you may review the presented data in the publications below.
HeFH, heterozygous familial hypercholesterolemia; LDL-C, low-density lipoprotein cholesterol; PCSK9i, proprotein convertase subtilisin/kexin type 9 inhibitor. *Indicated as an adjunct to diet and exercise to reduce LDL-C in adults with hypercholesterolemia, including HeFH.2 †Store refrigerated at 2°C to 8°C (36°F to 46°F). LEROCHOL may be kept at room temperature up to 25°C (77°F) in the original carton and must be used within 3 months of being removed from the refrigerator. If not used within 3 months, discard LEROCHOL.2
References: 1. Klug EQ, Llerena S, Burgess LJ, et al. Efficacy and safety of lerodalcibep in patients with or at high risk of cardiovascular disease: a randomized clinical trial. JAMA Cardiol. 2024;9(9):800-807. 2. Lerochol [prescribing information]. LIB Therapeutics; 2026. 3. Raal F, Fourie N, Scott R, et al. Long-term efficacy and safety of lerodalcibep in heterozygous familial hypercholesterolaemia: the LIBerate-HeFH trial. Eur Heart J. 2023;44(40):4272-4280.